| Cat.No.: | BSM-0315 |
| Product Name: | NSC 697923 |
| CAS No.: | 343351-67-7 |
| Figure: |
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| Product Overview: | A selective inhibitor of Ubc13 |
| Description: | NSC 697923 is a selective inhibitor of the E2 ubiquitin-conjugating enzyme Ubc13 when heterodimerized with Uev1A, blocking polyubiquitin chain formation at concentrations of 0.5 to 2 µM in vitro. It also inhibits NF-κB activation by PMA and other agonists, presumably through its effects on Ubc13. NSC 697923 blocks proliferation and induces apoptosis in diffuse large B cell lymphoma and neuroblastoma cells. It has antitumor efficacy in vivo in neuroblastoma orthotopic xenografts, when given intraperitoneally. |
| Appearance: | A solid |
| Molecular Weight: | 267.3 |
| Purity: | ≥98% |
| Storage: | -20°C |
| Targets: | Ubc13 |
| Molecular Formula: | C11H9NO5S |
| Chemical Name: | 2-[(4-methylphenyl)sulfonyl]-5-nitro-furan |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0026 | Human UBAP1 Knockout Cell Line | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0162 | Synthetic Human Ubiquitin protein (Biotin) | Inquiry |
| SP-0163 | Human Ubiquitin peptide | Inquiry |
| ◆ Antibodies | ||
| EAb-0174 | UBE2G1 Polyclonal Antibody | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0315 | NSC 697923 | Inquiry |
| Related Gene / Proteins | |||
| UB2D1 | UB2D2 | UB2D3 | UB2R1 |
| UBA1 | UBA5 | UBA7 | UBAP1 |
| UBB | UBC | UBC12 | Ubc13 |
| Ubc3B | UbcH1 | UbcH2 | UbcH3 |
| UbcH5a | UbcH5b | UbcH5c | UbcH8 More > |
| UBD | UBE1L | UBE2B | UBE2C |
| UBE2D1 | UBE2D3 | UBE2DNL | UBE2E1 |
| UBE2E2 | UBE2E3 | UBE2G1 | UBE2G2 |
| UBE2H | UBE2I | UBE2K | UBE2L3 |
| UBE2L6 | UBE2M | UBE2N | UBE2O |
| UBE2Q2 | UBE2R1 | UBE2R2 | UBE2T |
| UBE2V1 | UBE2V2 | UBE2W | UBE3A |
| Ube4a | Ubiquitin | UBL7 | Ubn1 |
| UBP5 | UBR2 | UBTD1 | UBTD2 |
| UBXN10 | UBXN2B | UBXN6 | UBXN8 |
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