| Cat.No.: | BSM-0260 |
| Product Name: | WT-161 |
| CAS No.: | 1206731-57-8 |
| Figure: |
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| Synonyms: | (E)-8-(2-(4-(Diphenylamino)benzylidene)hydrazinyl)-N-hydroxy-8-oxooctanamide |
| Description: | WT-161 is a potent, selective, and bioavailable HDAC6 (histone deacetylase-6) inhibitor (IC₅₀ 0.40 nM). It is selective for HDAC6 over HDAC3 (IC₅₀ = 51.61 nM) and induces α-tubulin acetylation, an HDAC6-dependent process, with minimal effect on global lysine acetylation. WT161 inhibits growth of patient-derived multiple myeloma cell lines with IC₅₀ values ranging from 1.5 to 4.7 μM. WT161 enhances the cytotoxicity of bortezomib and carfilzomib against patient-derived multiple myeloma cells. |
| Appearance: | Crystalline solid |
| Molecular Weight: | 458.56 |
| Purity: | ≥98% by HPLC |
| Storage: | -20°C |
| Targets: | HDAC6 (histone deacetylase-6) |
| Molecular Formula: | C₂₇H₃₀N₄O₃ |
| MDL Number: | MFCD12912450 |
| Solubility: | DMSO |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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