| Cat.No.: | BSM-0258 |
| Product Name: | WP-1130 |
| CAS No.: | 856243-80-6 |
| Figure: |
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| Synonyms: | (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide; Degrasyn |
| Description: | Cell-permeable. WP1130 acts as a partly selective DUB (deubiquitinases) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37, which are known to regulate survival protein stability and 26S proteasome function. WP1130-mediated inhibition of tumor-activated DUBs results in downregulation of antiapoptotic and upregulation of proapoptotic proteins, such as MCL-1 and p53. Blocks JAK2 signaling via JAK2 ubiquitination. |
| Appearance: | Pale yellow solid |
| Molecular Weight: | 384.27 |
| Purity: | ≥98% by TLC |
| Storage: | -20°C |
| Targets: | DUB (deubiquitinases) |
| Molecular Formula: | C₁₉H₁₈BrN₃O |
| MDL Number: | MFCD00078604 |
| Solubility: | DMSO (40 mg/ml) or EtOH (25 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0117 | DUB Inhibitor, PR-619 | Inquiry |
| ◆ Cell Lines | ||
| CL-0187 | Human DUSP3 Knockout Cell Line | Inquiry |
| CL-0203 | Human DUSP19 Knockout Cell Line | Inquiry |
| CL-0231 | Human DUSP18 Knockout Cell Line | Inquiry |
| CL-0232 | Human DUSP4 Knockout Cell Line | Inquiry |
| Related Gene / Proteins | |||
| DUB | DUSP1 | DUSP10 | DUSP11 |
| DUSP12 | DUSP13 | DUSP14 | DUSP15 |
| DUSP16 | DUSP18 | DUSP19 | DUSP2 |
| DUSP21 | DUSP22 | DUSP23 | DUSP26 |
| DUSP28 | DUSP3 | DUSP4 | DUSP6 More > |
| DUSP7 | DUSP8 | ||
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