| Cat.No.: | BSM-0249 |
| Product Name: | UNC0638 |
| CAS No.: | 1255580-76-7 |
| Figure: |
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| Synonyms: | 2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine |
| Product Overview: | Apotent G9a HMTase inhibitor |
| Description: | UNC0638 is a selective inhibitor of G9a and G9a-like protein (GLP), also known as EHMT1, with IC50's in the very low (<20) nM range. UNC0638 inhibits GLP with an IC50 value of 19 nM, but is more than 10,000-fold selective against SET7/9 (a H3K4 HMTase), SET8 (a H4K20 HMTase), PRMT3, and SUV39H2. UNC0638 inhibits H3K9 dimethylation in MDA-MB231 cells with an IC50 value of 81 nM and demonstrates favorable separation of functional and toxic effect. |
| Appearance: | Off-white solid |
| Molecular Weight: | 509.72 |
| Purity: | ≥98% by HPLC |
| Storage: | -20°C |
| Targets: | G9a HMTase; EHMT2 |
| Molecular Formula: | C30H47N5O2 |
| MDL Number: | MFCD17215972 |
| Solubility: | DMSO (10 mM) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0025 | BIX01294 (hydrochloride hydrate) | Inquiry |
| BSM-0026 | UNC0224 | Inquiry |
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Cell Lines | ||
| CL-0059 | Human EHMT1 Knockout Cell Line 7bp deletion | Inquiry |
| CL-0060 | Human EHMT2 Knockout Cell Line 34bp deletion | Inquiry |
| Related Gene / Proteins | |||
| EHD2 | EHMT1 | EHMT2 | |
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