| Cat.No.: | BSM-0211 |
| Product Name: | SB1518 (Pacritinib) |
| CAS No.: | 937272-79-2 |
| Figure: |
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| Synonyms: | 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene |
| Description: | A potent JAK2/FLT3 inhibitor. Displays equipotent activity against JAK2 (I₅₀ = 23 nM) and FLT3 (IC₅₀ = 22 nM). SB1518 displays potent anti-proliferative effects on myeloid and lymphoid cell lines driven by mutant or wild-type JAK2 or FLT3, resulting from cell cycle arrest and induction of apoptosis. |
| Appearance: | Crystalline solid |
| Molecular Weight: | 472.58 |
| Purity: | ≥98% by HPLC |
| Storage: | -20°C |
| Targets: | JAK2/FLT3 |
| Molecular Formula: | C₂₈H₃₂N₄O₃ |
| MDL Number: | MFCD12912446 |
| Solubility: | DMSO |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0001 | KW 2449 | Inquiry |
| BSM-0002 | AT9283 | Inquiry |
| BSM-0014 | ENMD-2076 L-(+)-Tartaric acid | Inquiry |
| BSM-0020 | ENMD-2076 | Inquiry |
| ◆ Cell Lines | ||
| CL-0017 | Human JARID2 Knockout Cell Line 11bp deletion | Inquiry |
| Related Gene / Proteins | |||
| Flt1 | Flt3 | Flt4 | JADE1 |
| JAK | JAK1 | JAK2 | JAK3 |
| JAKMIP1 | JARID | JARID1 | JARID1A |
| JARID1B | JARID1C | JARID2 | |
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