| Cat.No.: | BSM-0154 |
| CAS No.: | 732302-99-7 |
| Figure: |
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| Synonyms: | [6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate hydrochloride, monohydrate; Givinostat |
| Description: | ITF2357 is an orally active, hydroxamic-containing pan-histone deacetylase (HDAC) inhibitor with broad anti-inflammatory properties. ITF2357 inhibits both Class I and II HDACs and reduces caspase-1 activity in human peripheral blood mononuclear cells and the secretion of IL-1β and other cytokines at 25-100 nM. |
| Appearance: | Crystalline solid |
| Molecular Weight: | 475.97 |
| Purity: | ≥98% by HPLC |
| Storage: | -20°C |
| Targets: | Histone deacetylase (HDAC) |
| Molecular Formula: | C₂₄H₂₇N₃O₄.HCl.H₂O |
| MDL Number: | MFCD22580424 |
| Solubility: | DMSO (~30 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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