| Cat.No.: | BSM-0153 |
| Product Name: | IOX2 |
| CAS No.: | 931398-72-0 |
| Figure: |
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| Synonyms: | N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine |
| Description: | IOX-2 is a potent, cell-permeable and selective inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC₅₀ = 21 nM). It displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3. |
| Appearance: | White solid |
| Molecular Weight: | 352.34 |
| Purity: | ≥98% by HPLC |
| Storage: | -20°C |
| Targets: | HIF-1α prolyl hydroxylase-2 (PHD2) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3 |
| Molecular Formula: | C₁₉H₁₆N₂O₅ |
| MDL Number: | MFCD22580424 |
| Solubility: | DMSO (>30 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Nucleosomes | ||
| NUC-0007 | Recombinant Tetranucleosomes H3.3 | Inquiry |
| NUC-0008 | Recombinant Mononucleosomes H3.3 | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0009 | Histone H4 peptide (1-21), Biotin-labeled | Inquiry |
| SP-0010 | Histone H4 peptide (1-21) | Inquiry |
| SP-0012 | Histone H3 peptide (21-44), Biotin-labeled | Inquiry |
| Related Gene / Proteins | |||
| HIC1 | HIF1A | HIF1AN | HINFP |
| HIPK1 | HIPK2 | HIRA | Histone |
| Histone H1 | Histone H2A | Histone H2B | Histone H3 |
| Histone H4 | HIV-1 reverse transcriptase | JMJD | JMJD1A |
| JMJD1B | JMJD1C | JMJD2 | JMJD2A More > |
| JMJD2B | JMJD2C | JMJD2D | JMJD2E |
| JMJD2F | JMJD3 | JMJD4 | JMJD5 |
| JMJD6 | |||
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