| Cat.No.: | BSM-0143 |
| CAS No.: | 1346574-57-9 |
| Figure: |
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| Synonyms: | 1-Isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-6-(2-(4-methylpiperazin-1-yl)pyridine-4-yl)-1H-indazole-4-carboxamide |
| Description: | A potent histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor (IC₅₀ = 4 nM). Diplays 1000-fold selectivity for other HMTs except EZH1 (60-fold selectivity). GSK343 inhibits H3K27 methylation in HCC1806 cells with an IC₅₀ of <200nM (measured by immunofluorescence). |
| Appearance: | Crystalline solid |
| Molecular Weight: | 541.69 |
| Purity: | ≥99% by HPLC |
| Storage: | -20 ̊C |
| Targets: | EZH2 |
| Molecular Formula: | C₃₁H₃₉N₇O₂ |
| MDL Number: | MFCD22683852 |
| Solubility: | DMSO |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0006 | GSK343 | Inquiry |
| BSM-0059 | 3-Deazaneplanocin A | Inquiry |
| BSM-0060 | 3-Deazaneplanocin A hydrochloride | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0024 | Recombinant Human EZH1 293 Cell Lysate | Inquiry |
| EL-0025 | Recombinant Human EZH2 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| ezh1 | EZH2 | ||
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