| Cat.No.: | BSM-0094 |
| Product Name: | C646 |
| CAS No.: | 328968-36-1 |
| Figure: |
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| Synonyms: | (E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid |
| Product Overview: | A reversible, p300/CBP (CREB-binding protein) histone acetyltransferase (HAT) inhibitor |
| Description: | Potent and selective inhibitor of the histone acetyltransferase p300/CBP (Ki = 400 nM). Induces apoptosis in prostate cancer cells. Enhances fear extinction memory and synaptic plasticity in mice. Promotes tau deacetylation reducing levels of pathogenic p-tau. Cell permeable. |
| Appearance: | Red solid |
| Molecular Weight: | 445.42 |
| Purity: | ≥98% by NMR |
| Storage: | -20°C |
| Targets: | p300/CBP |
| Molecular Formula: | C24H19N3O6 |
| MDL Number: | MFCD01784780 |
| Solubility: | DMSO (25 mM) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0038 | CTPB | Inquiry |
| BSM-0073 | Anacardic Acid | Inquiry |
| BSM-0094 | C646 | Inquiry |
| ◆ Cell Lines | ||
| CL-0055 | Human CREBBP Knockout Cell Line 1bp insertion | Inquiry |
| CL-0061 | Human EP300 Knockout Cell Line 13bp deletion | Inquiry |
| Related Gene / Proteins | |||
| CREB | CREB3 | crebbp | CRISP1 |
| CRISP3 | CRP | EP300 | EPC1 |
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