| Cat.No.: | BSM-0093 |
| Product Name: | (+)-JQ1 |
| CAS No.: | 1268524-70-4 |
| Figure: |
-JQ1-1.jpg)
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| Abbr: | (+)-JQ1(BRD2, BRD3, BRD4, BRDT) |
| Synonyms: | JQ1 (+/-); JQ1 racemic; (6R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester |
| Product Overview: | A potent and highly specific BET inhibitor |
| Description: | A specific inhibitor of the BET family of acetyl-lysine recognition motifs, including the BRD2, BRD3, BRD4 and BRDT bromodomains. (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~ 50 and 90 nM, respectively. The binding is competitive with acetyl lysine. (+)-JQ1 can be a useful chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis. |
| Appearance: | Off-white solid |
| Molecular Weight: | 456.99 |
| Purity: | ≥98% by HPLC |
| Storage: | -20°C |
| Targets: | BET Bromodomain, BRD2, BRD3, BRD4, BRDT |
| Molecular Formula: | C23H25ClN4O2S |
| Chemical Name: | t-Butyl-2-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate |
| MDL Number: | MFCD19443648 |
| Solubility: | DMSO (10 mM) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Synthetic Peptides | ||
| SP-0001 | Bromodomain Non-Acetylated Ligand 4 | Inquiry |
| SP-0002 | Bromodomain Non-Acetylated Ligand 3 | Inquiry |
| SP-0003 | Bromodomain Non-Acetylated Ligand 1 | Inquiry |
| SP-0004 | Bromodomain Ligand 3 | Inquiry |
| SP-0005 | BET Bromodomain Ligand | Inquiry |
| Related Gene / Proteins | |||
| BET | BRCA1 | BRCA2 | BRCC3 |
| BRD | brd1 | brd2 | brd3 |
| brd4 | BRD7 | BRD8 | brd9 |
| brdt | BRL | BRM | BRMS1 |
| BRPF1 | BRPF2 | brpf3 | BRWD1 More > |
| BRWD3 | |||
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