| Cat.No.: | BSM-0074 |
| CAS No.: | 183506-66-3 |
| Figure: |
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| Abbr: | Apicidin(HDAC3, HDAC6) |
| Synonyms: | Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinexcarbonyl] |
| Description: | Cyclopeptide inhibitor of histone deacetylases (HDACs). Inhibits HeLa cell proliferation (IC50 = 50-100 nM) and induces reversible transcriptional activation of p21 (WAF1). Decreases HIF1α protein levels and transcriptional activity in human and mouse tumor cell lines. Cell permeable. |
| Appearance: | Off-white solid |
| Molecular Weight: | 623.8 |
| Purity: | ≥95% by HPLC |
| Storage: | -20°C |
| Targets: | HDAC |
| Molecular Formula: | C34H49N5O6 |
| MDL Number: | MFCD03452661 |
| Solubility: | DMSO (50 mg/ml) of EtOH |
| Shipping Conditions: | RT |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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