| Cat.No.: | BSM-0053 |
| Product Name: | UNC-2170 |
| CAS No.: | 1648707-58-7 |
| Figure: |
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| Synonyms: | 3-Bromo-N-(3-(ter-butylamino)propyl)benzamide, hydrochloride |
| Description: | The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-stranded DNA breaks. UNC-2170, identified by screening, was found to be a µM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The compound functions as 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain. |
| Appearance: | White powder. |
| Molecular Weight: | 349.7 |
| Purity: | >98% (TLC); NMR (Conforms) |
| Storage: | Store desiccated as supplied at -20° for up to 2 years. Store solutions at -20°C for up to 3 months. |
| Targets: | Methyl-lysine binding protein 53BP1 |
| Molecular Formula: | C14H21BrN2O • HCl |
| Solubility: | Dissolved in DMSO (40 mg/ml); or water (50 mg/ml). |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0013 | TP2 Polyclonal Antibody | Inquiry |
| EAb-0623 | p53 Monoclonal Antibody | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0053 | UNC-2170 | Inquiry |
| BSM-0324 | UNC2170 (maleate) | Inquiry |
| ◆ Cell Lines | ||
| CL-0438 | Human TP53BP1 Knockout Cell Line 40bp deletion | Inquiry |
| Related Gene / Proteins | |||
| TP2 | TP53BP1 | ||
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