| Cat.No.: | BSM-0052 |
| Product Name: | Tubastatin A hydrochloride |
| CAS No.: | 1310693-92-5 |
| Figure: |
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| Synonyms: | Tubastatin A, N-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol-5(2H)-yl)methyl)benzamide, hydrochloride |
| Description: | Potent and selective histone deacetylase 6 (HDAC 6) inhibitor (IC50 = 15 nm; >1000-fold selective against other HDACs and 60-fold for HDAC8). Inhibits TNFα (IC50 = 272 nm) and IL-6 (IC50 = 712 nm) in LPS-stimulated human macrophages and displays anti-inflammatory activity in animal models. Improves survival in animal models of sepsis. Improves cognition in Alzheimers disease transgenic mice. Cell permeable. |
| Appearance: | White powder. |
| Molecular Weight: | 371.9 |
| Purity: | 99% (HPLC); NMR (Conforms) |
| Storage: | Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months. |
| Targets: | HDAC6 |
| Molecular Formula: | C20H21N3O2 • HCl |
| Solubility: | Dissolved in DMSO (50 mg/ml). |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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