| Cat.No.: | BSM-0043 |
| Product Name: | NSC-663284 |
| CAS No.: | 383907-43-5 |
| Figure: |
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| Synonyms: | NSC-663284, 6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione |
| Description: | Potent and selective inhibitor of the protein lysine methyltransferase SETD8 (IC50 = 0.21 µM) which efficiently suppresses cellular H4K20me1 at doses lower than 5 µM. Also inhibits CDC25 phosphatases. Arrests cells at G1 and G2/M and inhibits cdk1 and 2 activation. Inhibits the growth of a variety of human tumor cell lines. |
| Appearance: | Red powder. |
| Molecular Weight: | 321.8 |
| Purity: | >98% (TLC); NMR (Conforms) |
| Storage: | Store desiccated as supplied at -20° for up to 2 years. Store solutions at -20°C for up to 1 month. |
| Targets: | SETD8 |
| Molecular Formula: | C15H16ClN3O3 |
| Solubility: | Dissolved in DMSO (15 mg/ml); or ethanol (55 mg/ml). |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-0030 | SETD8 Polyclonal Antibody | Inquiry |
| EAb-0031 | SETDB1 Polyclonal Antibody | Inquiry |
| EAb-0032 | Setd1a Polyclonal Antibody | Inquiry |
| EAb-0033 | Setd1b Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| SENP3 | SENP8 | SET | SET1 |
| SET2 | SET7 | SET8 | SET9 |
| SETBP1 | SETD1A | SETD1B | SETD2 |
| SETD3 | SETD5 | SETD6 | SETD7 |
| SETD8 | SETD9 | SetDB1 | SETDB2 More > |
| SETMAR | |||
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