| Cat.No.: | BSM-0042 |
| CAS No.: | 18378-89-7 |
| Figure: |
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| Synonyms: | Mithramycin A, A 2371, Antibiotic LA 7017, Aureolic Acid, NSC 24559, PA 144, Plicamycin |
| Description: | Inhibits DNA methyltransferase. A selective Sp1 inhibitor, it binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, inhibiting their expression. Mithramycin A (at 10-200 nM) sensitizes tumor cells to TRAIL-induced apoptosis. |
| Appearance: | Yellow powder. |
| Molecular Weight: | 1085.2 |
| Purity: | >98% (HPLC); NMR (Conforms) |
| Storage: | Store desiccated as supplied at -20° for up to 2 years. Store solutions at -20°C for up to 1 month. |
| Molecular Formula: | C52H76O24 |
| Solubility: | Dissolved in DMSO (20 mg/ml); or ethanol (10 mg/ml). |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0008 | Vinorelbine Tartrate | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0027 | Recombinant Human DNMT3A 293 Cell Lysate | Inquiry |
| EL-0028 | Recombinant Human DNMT3B 293 Cell Lysate | Inquiry |
| EL-0029 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| EL-0030 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| DNA alkyltransferase | DNAJC2 | DNAS1L1 | DNASE1L3 |
| DNMT | DNMT1 | DNMT2 | DNMT3A |
| DNMT3B | DNMT3L | DNMT4 | |
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