| Cat.No.: | BSM-0040 |
| CAS No.: | 658084-64-1 |
| Figure: |
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| Description: | Nicotinamide phosphoribosyltransferase (Nampt) inhibitor (Ki = 0.4 nM). FK-866 is a highly specific non-competitive inhibitor of Nampt causing gradual NAD+ depletion. Induces tumor cell apoptosis and causes premature senescence in normal human smooth muscle cells which may be linked to decreased activity of the NAD+-dependent enzyme SIRT1. Extends lifespan of human cells. Cell permeable. |
| Appearance: | Off white powder (hygroscopic), MP = 92-96°C. |
| Molecular Weight: | 428 |
| Purity: | >98% (TLC); NMR (Conforms) |
| Storage: | Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 2 months. |
| Targets: | Nampt |
| Molecular Formula: | C24H29N3O2 • HCl |
| Solubility: | Dissolved in water (40 mg/ml). |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0040 | FK-866 HCl | Inquiry |
| BSM-0201 | Remodelin | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0051 | Recombinant Human NACC2 Cell Lysate | Inquiry |
| EL-0085 | Recombinant Human NAP1L2 293 Cell Lysate | Inquiry |
| EL-0158 | Recombinant Human NASP 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| NAA38 | NAA60 | NACC2 | Nampt |
| Nanog | Nanos3 | Nap1 | NAP1L1 |
| NAP1L2 | NAP1L4 | NARG1 | NASP |
| NAT10 | NAT14 | ||
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