| Cat.No.: | BSM-0003 |
| Product Name: | PHA-680632 |
| CAS No.: | 398493-79-3 |
| Molecular Weight: | 501.62 |
| Purity: | >99% |
| Storage: | 2 years at -20°C |
| Targets: | Aurora A |
| Molecular Formula: | C28H35N7O2 |
| Solubility: | No |
| In Vitro: | PHA-680632 potently inhibits all three Aurora kinases (A, B, and C) with IC50 values of 27, 135, and 120 nM, respectively. PHA-680632 (0.5 uM) causes polyploidy in tumor cells. The mechanism of action of PHA-680632 is in agreement with inhibition of Aurora kinases. PHA680632 in association with radiation leads to additive effects in cancer cells, especially in the p53-deficient cells. |
| Warning: | For Research Use Only! Not For Use in Humans. |
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