| Cat.No.: | EKIT-0567 |
| Product Name: | DNA Methylation ELISA Kit |
| Size: | 96 solid reactions;96 strip reactions;480 solid reactions;480 strip reactions |
| Product Overview: | A competitive ELISA for the quantification of 5- methyl- 2'- deoxy cytidine |
| Description: | DNA Methylation ELISA Kit is a competitive assay that can be used for the quantification of 5-methyl-2'-deoxy cytidine in urine, culture supernatants, plasma, and other sample matrices. |
| Background: | DNA methylation is an important epigenetic process regulating gene expression. Methylation occurs on carbon 5 of 2'-deoxy-cytidine yielding the modified base 5-methyl-2'-deoxy cytidine. The methylation pattern of cells is tightly regulated during development with the methylation profile being transmitted from parent to daughter cells during cell division. Methylation results in long-term silencing of genes, while unmethylated regions of DNA can be actively transcribed. Global changes in methylation can be quantified by measuring plasma or urinary levels of 5-methyl-2'-deoxy cytidine. These changes in methylation can provide valuable information about cancer status of an individual. For example, patients with leukemia excrete significantly elevated levels of 5-methyl-2'-deoxy cytidine compared to healthy individuals. Global methylation within tissues can be measured in a similar manner, allowing study of tissue-specific changes that occur as a result of differentiation, aging, or carcinogenesis. |
| Features & Benefits: | Measure 5-methyl-2’-deoxy cytidine in urine, plasma, cell lysates, and tissue culture supernatants; Assay 24 samples in triplicate or 36 samples in duplicate; Measure 5-methyl-2’-deoxy cytidine levels down to 3 ng/ml |
| Storage: | -20°C |
| Warning: | For research use only, not for diagnostic use. |
| Product Types | ||
| ◆ Research Kits | ||
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USA
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