Recombinant SETD2 (1392-2564) protein

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Cat.No.:  PE-3679
Product Name:  Recombinant SETD2 (1392-2564) protein
Product Overview:  Recombinant SETD2 (1392-2564) (accession number NP_054878.5) was expressed in Sf9 cells and contains an N-terminal FLAG-Tag with an observed molecular weight of 134 kDa. The recombinant protein is >85% pure by SDS-PAGE.
Background:  SETD2 (SET Domain Containing 2) is a histone methyltransferase that methylates histone H3 at lysine 36. H3K36 methylation is associated with active chromatin. SETD2 also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA pol II. Recombinant SETD2 (1392-2564) includes amino acids 1392-2564 that contains the SET domain of SETD2 that catalyzes methylation of lysine residues.
Applications:  Suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
Storage:  Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles.
Appearance:  Liquid
Species:  Human
Formulation:  25 mM HEPES- NaOH pH 7.5, 300 mM NaCl, 5% glycerol, 0.04% Triton X-100, 0.2 mM TCEP.
Tag:  FLAG
Expression System:  Baculovirus
Warning:  This product is for research use only. Not for use in diagnostic or therapeutic procedures.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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