| Cat.No.: | PE-3039 |
| Product Name: | SET7/9 Methyltransferase |
| Description: | SET7/9 (SETD7) is a SET domain-containing histone (lysine) methyltransferase, specific for monomethylation. SET7/9 was originally described as a histone H3 lysine-4 (H3K4) monomethyltransferase. While it does produce this mark (H3K4me) in vitro with peptide substrates or recombinant histone H3, its activity with nucleosomes is poor. Recent work has shown SET7/9 to function in the regulation and methylation of multiple non-histone regulatory factors including p53, p65, pRB,TAF10, SIRT1, DNMT1, the androgen receptor (AR), the farnesoid X receptor (FXR) and estrogen receptor a (ER). SET7/9 action as a coactivator for AR and its promotion of androgen-dependent cell proliferation suggests it as a potential target for prostate cancer therapy. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 68.5 kDa |
| Formulation: | Solution of purified recombinant protein in 50 mM Tris/HCl, pH 8.0, 500 mM NaCl, 10% (v/v) glycerol, 2 mM TCEP. |
| Accession#: | NM_030648 |
| Tag: | GST & His |
| Protein Length: | 2-366 (C-term.) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-0030 | SETD8 Polyclonal Antibody | Inquiry |
| EAb-0031 | SETDB1 Polyclonal Antibody | Inquiry |
| EAb-0032 | Setd1a Polyclonal Antibody | Inquiry |
| EAb-0033 | Setd1b Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| SENP3 | SENP8 | SET | SET1 |
| SET2 | SET7 | SET8 | SET9 |
| SETBP1 | SETD1A | SETD1B | SETD2 |
| SETD3 | SETD5 | SETD6 | SETD7 |
| SETD8 | SETD9 | SetDB1 | SETDB2 More > |
| SETMAR | |||
USA
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