| Cat.No.: | PE-3018 |
| Product Name: | NSD1 Methyltransferase |
| Description: | NSD1 is a SET-domain lysine methyltransferase that exerts regulatory effects primarily through dimethylation of H3K36, NSD1 may also act as an H4K20 and NF-kB p65 (K218, K221) methyltransferase. While H3K36me2 is considered a gene-activating mark, NSD1 contains distinct domains that interact with liganded and unliganded nuclear receptors and can act as either a coactivator or corepressor. Chromosomal translocations resulting in the expression of a nucleoporin-98 (NUP98)-NSD1 fusion protein are implicated in the development of a subset of acute myeloid leukemias (AMLs) with a particularly poor prognosis, an oncogenic effect which requires NSD1’s H3K36 methyltransferase activity. A variety of results suggest a complex and context-dependent role for NSD1 in oncogenesis, including the elevated cancer risk associated with NSD1 haploinsufficiency in Sotos syndrome, NSD1’s tumor-suppressive effects in neuroblastoma and the fact that it is downregulated in primary prostate tumors (recurrent cancers), while upregulated in metastatic prostate tumors. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 130.9 kDa |
| Formulation: | Solution of purified recombinant protein in 50 mM Tris/HCl pH 7.5, 500 mM NaCl, 1 mM TCEP, 10% glycerol (v/v). |
| Accession#: | NM_022455 |
| Tag: | His |
| Protein Length: | 1538-2696 (end) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0113 | Human NSD1 Knockout Cell Line 4bp deletion | Inquiry |
| ◆ Research Kits | ||
| EKIT-0287 | NSD1 Chemiluminescent Assay Kit | Inquiry |
| EKIT-0494 | NSD3 Chemiluminescent Assay Kit | Inquiry |
| EKIT-0498 | NSD3 Chemiluminescent Assay Kit | Inquiry |
| EKIT-0502 | NSD2 Chemiluminescent Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| nsd1 | NSD2 | NSD3 | NSMCE2 |
| NSUN1 | NSUN2 | NSUN3 | NSUN4 |
| NSUN5 | NSUN6 | NSUN7 | |
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