| Cat.No.: | PE-2855 |
| Product Name: | Recombinant Human RUNX1 / AML1 protein |
| Background: | CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation. |
| Applications: | Functional Studies; SDS-PAGE |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | 33 kDa including tags |
| Purity: | > 90 % SDS-PAGE. Expressed in E.coli as inclusion bodies, refolded, chromatographically purified and sterile filtered. |
| Species: | Human |
| Formulation: | pH: 8.00; Constituent: 0.32% Tris HClNote: Contains NaCl,EDTA,KCl,arginine,DTT and Glycerol |
| Accession#: | Q01196-3 |
| Alternative Names: | Acute myeloid leukemia 1/Acute myeloid leukemia 1 protein/alpha subunit core binding factor |
| Amino Acid Sequence: | 29aa_Tag_RIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAG KLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVV ALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGR GKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSL SFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQE EDTAPWRCLEESGGGGSPGRRRRRRRRRRR |
| Sequence Similarities: | Contains 1 Runt domain. |
| Expression System: | E. coli |
| Post Translational Modifications: | Phosphorylated in its C-terminus upon IL-6 treatment. Phosphorylation enhances interaction with MYST3.Methylated. |
| Protein Length: | Full length protein; 2 to 250 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0042 | Runx1/AML1-ETO Polyclonal Antibody | Inquiry |
| EAb-0313 | RUNX2 Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0092 | Recombinant Human RUNX2 293 Cell Lysate | Inquiry |
| EL-0093 | Recombinant Human RUNX2 293 Cell Lysate | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0746 | Recombinant Human RUNX2 | Inquiry |
| Related Gene / Proteins | |||
| Runx1 | RUNX2 | RUVB2 | RUVBL1 |
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