| Cat.No.: | PE-2696 |
| Background: | Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site-selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression. |
| Applications: | SDS-PAGE |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Lyophilised |
| Molecular Weight: | 22 kDa |
| Species: | Human |
| Formulation: | Constituents: 0.32% Tris HCl, 0.58% Sodium chloride |
| Accession#: | P55265 |
| Alternative Names: | 136 kDa double-stranded RNA-binding protein/136kDa double stranded RNA binding protein/ADAR |
| Tag: | His |
| Sequence Similarities: | Contains 1 A to I editase domain.Contains 2 DRADA repeats.Contains 3 DRBM (double-stranded RNA-binding) domains. |
| Expression System: | E. coli |
| Post Translational Modifications: | Sumoylation reduces RNA-editing activity. |
| Protein Length: | Protein fragment; 892 to 1089 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0203 | ADNP Polyclonal Antibody | Inquiry |
| EAb-0370 | ADPRHL2 Polyclonal Antibody | Inquiry |
| ◆ Research Kits | ||
| EKIT-0580 | ADMA direct (mouse/rat) ELISA kit | Inquiry |
| EKIT-0581 | ADMA (human) ELISA kit | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-2174 | Recombinant Human ADAL protein (denatured) | Inquiry |
| Related Gene / Proteins | |||
| ADA | ADAL | ADAR1 | ADMA |
| ADNP | ADPRH | ADPRHL2 | |
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