| Cat.No.: | PE-2639 |
| Product Name: | Recombinant Human Dcp2/TDT protein |
| Background: | Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking a RNA moiety. |
| Applications: | ELISA; Western blot; SDS-PAGE |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | 68 kDa including tags |
| Species: | Human |
| Formulation: | pH: 8.00; Constituents: 0.31% Glutathione, 0.79% Tris HCl |
| Accession#: | Q8IU60-2 |
| Alternative Names: | DCP2/DCP2 decapping enzyme homolog (S. cerevisiae)/DCP2, S. cerevisiae, homolog of |
| Amino Acid Sequence: | METKRVEIPGSVLDDLCSRFILHIPSEERDNAIRVCFQIELAHWFYLDFY MQNTPGLPQCGIRDFAKAVFSHCPFLLPQGEDVEKVLDEWKEYKMGVPTY GAIILDETLENVLLVQGYLAKSGWGFPKGKVNKEEAPHDCAAREVFEETG FDIKDYICKDDYIELRINDQLARLYIIPGIPKDTKFNPKTRREIRNIEWF SIEKLPCHRNDMTPKSKLGLAPNKFFMAIPFIRPLRDWLSRRFGDSSDSD NGFSSTGSTPAKPTVEKLSRTKFRHSQQLFPDGSPGDQWVKHRQPLQQKP YNNHSEMSDLLKGKKCEKKLHPRKLQDNFETDAVYDLPSSSEDQLLEHAE GQPVACNGHCKFPFSSRAFLSFKFDHNAIMKILDL |
| Sequence Similarities: | Belongs to the Nudix hydrolase family. DCP2 subfamily.Contains 1 nudix hydrolase domain. |
| Expression System: | Wheat germ |
| Post Translational Modifications: | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| Protein Length: | Full length protein; 1 to 385 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0016 | TDRD4 Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0049 | Recombinant Human TDRD3 Cell Lysate | Inquiry |
| ◆ Cell Lines | ||
| CL-0285 | Human TDG Knockout Cell Line 2bp insertion | Inquiry |
| CL-0286 | Human TDGF1 Knockout Cell Line | Inquiry |
| CL-0405 | Human DCLRE1C Knockout Cell Line 4bp deletion | Inquiry |
| Related Gene / Proteins | |||
| DCAF4 | DCLRE1C | Dcp2 | DCTD |
| DCUN1D1 | DCUN1D2 | TDF | TDG |
| TDGF1 | TDP1 | TDRD12 | TDRD3 |
| TDRD4 | TDRD4 | TDT | |
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