| Cat.No.: | PE-2627 |
| Product Name: | Recombinant Human MCM6 protein |
| Background: | Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. |
| Applications: | ELISA; SDS-PAGE; Western blot |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | 116 kDa including tags |
| Species: | Human |
| Formulation: | pH: 8.00; Constituents: 0.3% Glutathione, 0.79% Tris HCl |
| Accession#: | Q14566 |
| Alternative Names: | DNA replication licensing factor MCM6/MCG40308/Mcm6 |
| Amino Acid Sequence: | MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLA EELIRPERNTLVVSFVDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKD RKEIPLAKDFYVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPE LVSGTFLCLDCQTVIRDVEQQFKYTQPNICRNPVCANRRRFLLDTNKSRF VDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIV VPDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLA CCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNL CTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPST AKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALM LADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSIL AAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIAR RIVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKH LRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFR LLNKSIIRVETPDVNLDQEEEIQMEVDEGAGGINGHADSPAPVNGINGYN EDINQESAPKASLRLGFSEYCRISNLIVLHLRKVEEEEDESALKRSELVN WYLKEIESEIDSEEELINKKRIIEKVIHRLTHYDHVLIELTQAGLKGSTE GSESYEEDPYLVVNPNYLLED |
| Sequence Similarities: | Belongs to the MCM family.Contains 1 MCM domain. |
| Expression System: | Wheat germ |
| Post Translational Modifications: | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| Protein Length: | Full length protein; 1 to 821 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0011 | Human MCF2L Knockout Cell Line | Inquiry |
| ◆ Antibodies | ||
| EAb-0068 | MCAF Polyclonal Antibody | Inquiry |
| EAb-0303 | MCM6 Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0161 | Recombinant Human MCRS1 293 Cell Lysate | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-1225 | Recombinant Human MCRS1, His-tagged | Inquiry |
| Related Gene / Proteins | |||
| MCAF1 | MCF2L | MCM6 | MCM8 |
| MCRS1 | |||
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