| Cat.No.: | PE-2575 |
| Product Name: | Recombinant Human TIS11D protein |
| Background: | mRNA-binding protein that plays a key role in self-renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit-erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation. |
| Applications: | Western blot; ELISA; SDS-PAGE |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | 78 kDa including tags |
| Species: | Human |
| Formulation: | pH: 8.00; Constituents: 0.31% Glutathione, 0.79% Tris HCl |
| Accession#: | P47974 |
| Alternative Names: | BRF2/Butyrate response factor 2/C3H1 type-like 2 |
| Amino Acid Sequence: | MSTTLLSAFYDVDFLCKTEKSLANLNLNNMLDKKAVGTPVAAAPSSGFAP GFLRRHSASNLHALAHPAPSPGSCSPKFPGAANGSSCGSAAAGGPTSYGT LKEPSGGGGTALLNKENKFRDRSFSENGDRSQHLLHLQQQQKGGGGSQIN STRYKTELCRPFEESGTCKYGEKCQFAHGFHELRSLTRHPKYKTELCRTF HTIGFCPYGPRCHFIHNADERRPAPSGGASGDLRAFGTRDALHLGFPREP RPKLHHSLSFSGFPSGHHQPPGGLESPLLLDSPTSRTPPPPSCSSASSCS SSASSCSSASAASTPSGAPTCCASAAAAAAAALLYGTGGAEDLLAPGAPC AACSSASCANNAFAFGPELSSLITPLAIQTHNFAAVAAAAYYRSQQQQQQ QQQQGLAPPAQPPAPPSATLPAGAAAPPSPPFSFQLPRRLSDSPVFDAPP SPPDSLSDRDSYLSGSLSSGSLSGSESPSLDPGRRLPIFSRLSISDD |
| Sequence Similarities: | Contains 2 C3H1-type zinc fingers. |
| Expression System: | Wheat germ |
| Protein Length: | Full length protein; 1 to 497 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0014 | TIP60 Polyclonal Antibody | Inquiry |
| EAb-0015 | TIP60 Polyclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-1664 | TRIM24 (TIF1), GST-tag | Inquiry |
| PE-1667 | TRIM24 (TIF1), His-tag | Inquiry |
| PE-1887 | TIP60 (human recombinant) | Inquiry |
| Related Gene / Proteins | |||
| TIAL1 | TIEG1 | TIF1 | TIGD4 |
| TIGD5 | TIP49A | TIP49B | TIP60 |
| TIS11D | |||
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