| Cat.No.: | PE-2349 |
| Background: | Histone demethylase that specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. |
| Applications: | SDS-PAGE; ELISA; Western blot |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | pH: 8.00; Constituents: 0.31% Glutathione, 0.79% Tris HCl |
| Accession#: | Q9H6W3 |
| Alternative Names: | 60S ribosomal protein L8 histidine hydroxylase/C14orf169/Chromosome 14 open reading frame 169 |
| Tag: | GST |
| Amino Acid Sequence: | MDGLQASAGPLRRGRPRRRRKPQPHSGSVLALPLRSRKIRKQLRSVVSRM AALRTQTLPSENSEESRVESTADDLGDALPGGAAVAAVPDAARREPYGHL GPAELLEASPAARSLQTPSARLVPASAPPARLVEVPAAPVRVVETSALLC TAQHLAAVQSSGAPATASGPQVDNTGGEPAWDSPLRRVLAELNRIPSSRR RAARLFEWLIAPMPPDHFYRRLWEREAVLVRRQDHTYYQGLFSTADLDSM LRNEEVQFGQHLDAARYINGRRETLNPPGRALPAAAWSLYQAGCSLRLLC PQAFSTTVWQFLAVLQEQFGSMAGSNVYLTPPNSQGFAPHYDDIEAFVLQ LEGRKLWRVYRPRAPTEELALTSSPNFSQDDLGEPVLQTVLEPGDLLYFP RGFIHQAECQDGVHSLHLTLSTYQRNTWGDFLEAILPLAVQAAMEENVEF RRGLPRDFMDYMGAQHSDSKDPRRTAFMEKVRVLVARLGHFAPVDAVADQ RAKDFIHDSLPPVLTDRERALSVYGLPIRWEAGEPVNVGAQLTTETEVHM LQDGIARLVGEGGHLFLYYTVENSRVYHLEEPKCLEIYPQQADAMELLLG SYPEFVRVGDLPCDSVEDQLSLATTLYDKGLLLTKMPLALN |
| Sequence Similarities: | Belongs to the MINA53/NO66 family. NO66 subfamily.Contains 1 JmjC domain. |
| Expression System: | Wheat germ |
| Protein Length: | Full length protein; 1 to 641 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0028 | Human C17orf49 Knockout Cell Line | Inquiry |
| ◆ Antibodies | ||
| EAb-1892 | Notch3 Monoclonal Antibody | Inquiry |
| EAb-1893 | Notch1 Monoclonal Antibody | Inquiry |
| EAb-1894 | NonO Polyclonal Antibody | Inquiry |
| EAb-2048 | C17orf96 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| C14orf169 | C14ORF21 | C17orf42 | C17orf49 |
| C17orf96 | C1D | NO66 | NOB1 |
| NOC2L | NonO | NOP58 | Notch1 |
| Notch3 | |||
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