| Cat.No.: | PE-2288 |
| Background: | Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. |
| Applications: | ELISA; Western blot |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | pH: 8.00; Constituents: 0.31% Glutathione, 0.79% Tris HCl |
| Alternative Names: | NET15/NET7/NIR |
| Tag: | GST |
| Amino Acid Sequence: | MAAAGSRKRRLAELTVDEFLASGFDSESESESENSPQAETREAREAARSP DKPGGSPSASRRKGRASEHKDQLSRLKDRDPEFYKFLQENDQSLLNFSDS DSSEEEEGPFHSLPDVLEEASEEEDGAEEGEDGDRVPRGLKGKKNSVPVT VAMVERWKQAAKQRLTPKLFHEVVQAFRAAVATTRGDQESAEANKFQVTD SAAFNALVTFCIRDLIGCLQKLLFGKVAKDSSRMLQPSSSPLWGKLRVDI KAYLGSAIQLVSCLSETTVLAAVLRHISVLVPCFLTFPKQCRMLLKRMVV VWSTGEESLRVLAFLVLSRVCRHKKDTFLGPVLKQMYITYVRNCKFTSPG ALPFISFMQWTLTELLALEPGVAYQHAFLYIRQLAIHLRNAMTTRKKETY QSVYNWQYVHCLFLWCRVLSTAGPSEALQPLVYPLAQVIIGCIKLIPTAR FYPLRMHCIRALTLLSGSSGAFIPVLPFILEMFQQVDFNRKPGRMSSKPI NFSVILKLSNVNLQEKAYRDGLVEQLYDLTLEYLHSQAHCIGFPELVLPV VLQLKSFLRECKVANYCRQVQQLLGKVQENSAYICSRRQRVSFGVSEQQA VEAWEKLTREEGTPLTLYYSHWRKLRDREIQLEISGKERLEDLNFPEIKR RKMADRKDEDRKQFKDLFDLNSSEEDDTEGFSERGILRPLSTRHGVEDDE EDEEEGEEDSSNSEDGDPDAEAGLAPGELQQLAQGPEDELEDLQLSEDD |
| Sequence Similarities: | Belongs to the NOC2 family. |
| Expression System: | Wheat germ |
| Protein Length: | Full length protein; 1 to 749 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-1892 | Notch3 Monoclonal Antibody | Inquiry |
| EAb-1893 | Notch1 Monoclonal Antibody | Inquiry |
| EAb-1894 | NonO Polyclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-2288 | Recombinant Human NOC2L protein | Inquiry |
| PE-2349 | Recombinant Human C14orf169 / NO66 protein | Inquiry |
| Related Gene / Proteins | |||
| NO66 | NOB1 | NOC2L | NonO |
| NOP58 | Notch1 | Notch3 | |
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