| Cat.No.: | PE-2197 |
| Product Name: | Recombinant Human KDM4A / JHDM3A / JMJD2A protein (Tagged) |
| Background: | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. |
| Applications: | SDS-PAGE |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | 42 kDa including tags |
| Purity: | > 90 % SDS-PAGE. |
| Species: | Human |
| Accession#: | O75164 |
| Alternative Names: | JHDM3A/JmjC domain containing histone demethylation protein 3A/JmjC domain-containing histone demethylation protein 3A |
| Amino Acid Sequence: | NLERAKGALQSITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSF SDNLYPEDIVSQDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQ VEFEDGSQLVVKRDDVYTLDEELPKRVKSRLSVASD |
| Sequence Similarities: | Belongs to the JHDM3 histone demethylase family.Contains 1 C2HC pre-PHD-type zinc finger.Contains 1 JmjC domain.Contains 1 JmjN domain.Contains 2 PHD-type zinc fingers.Contains 2 Tudor domains. |
| Expression System: | E. coli |
| Post Translational Modifications: | Ubiquitinated by RNF8 and RNF168 following DNA damage, leading to its degradation. Degradation promotes accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited. |
| Protein Length: | Protein fragment; 888 to 1023 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0015 | Human KDM5B Knockout Cell Line 14bp deletion | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-0071 | KDM1B Polyclonal Antibody | Inquiry |
| EAb-0072 | JMJD6 Polyclonal Antibody | Inquiry |
| EAb-0074 | JMJD2c Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| JHDM1A | JHDM1B | JHDM1D | JHDM2A |
| JHDM3A | JMJD | JMJD1A | JMJD1B |
| JMJD1C | JMJD2 | JMJD2A | JMJD2B |
| JMJD2C | JMJD2D | JMJD2E | JMJD2F |
| JMJD3 | JMJD4 | JMJD5 | JMJD6 More > |
| KDM1 | KDM1A | KDM1B | KDM2 |
| KDM2A | KDM2B | KDM3A | KDM3B |
| KDM4 | KDM4A | KDM4B | KDM4C |
| KDM4D | KDM4E | KDM5 | KDM5A |
| KDM5B | KDM5C | KDM5D | KDM6A |
| KDM6B | KDM6C | KDM7 | KDM7A |
| KDM7B | KDM8 | ||
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