| Cat.No.: | PE-2196 |
| Product Name: | Recombinant Human KMT3C / SMYD2 protein |
| Background: | Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB. |
| Applications: | SDS-PAGE |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | 50 kDa including tags |
| Purity: | >80 % SDS-PAGE. |
| Species: | Human |
| Formulation: | pH: 8.00; Constituents: 0.71% Tris HCl, 0.72% Sodium chloride, 0.02% Potassium chloride, 0.05% DTT, 10% Glycerol. Contains 90 µg/ml DDDDK peptide. |
| Accession#: | Q9NRG4 |
| Alternative Names: | Histone methyltransferase SMYD2/HSKM B/HSKM-B |
| Tag: | DDDDK |
| Amino Acid Sequence: | MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGN HCEYCFTRKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENW NPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQ SDIAALHHFYSKHLGFPDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFP DVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYPTEDR NDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARN VIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVC LYMQDWEGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAA GEKALKKAIAIMEVAHGKDHPYISEIKQEIESH |
| Sequence Similarities: | Contains 1 MYND-type zinc finger.Contains 1 SET domain. |
| Expression System: | Sf9 Insect Cells |
| Protein Length: | Full length protein; 1 to 433 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0019 | SMARCA4 Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0063 | Recombinant Human SMARCC2 293 Cell Lysate | Inquiry |
| EL-0064 | Recombinant Human SMARCB1 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0080 | AZ-505 ditrifluoroacetate | Inquiry |
| ◆ Research Kits | ||
| EKIT-0120 | BRG1 bromodomain TR-FRET Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| KMT1B | KMT1E | KMT2A | KMT2B |
| KMT2C | KMT2D | KMT2E | KMT3A |
| KMT3B | KMT3C | KMT5A | KMT6 |
| SMAD3 | SMAD4 | SMARCA1 | SMARCA2 |
| SMARCA4 | SMARCA5 | SMARCA6 | SMARCAD1 More > |
| SMARCAL1 | SMARCB1 | SMARCC1 | SMARCC2 |
| SMARCD1 | SMARCD2 | SMARCD3 | SMARCE1 |
| SMC1-α | SMC3 | SMC4 | SMCHD1 |
| SMCX | SMN | SMN1 | SMN2 |
| SMOC2 | SMRT | SMT3 | SMUG1 |
| SMURF2 | SMYD1 | SMYD2 | SMYD2B |
| SMYD3 | SMYD4 | SMYD5 | |
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