| Cat.No.: | PE-2184 |
| Background: | Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. |
| Applications: | SDS-PAGE |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | 61 kDa including tags |
| Purity: | >55 % SDS-PAGE. |
| Species: | Human |
| Formulation: | pH: 8.00; Constituents: 0.63% Tris HCl, 0.64% Sodium chloride, 0.02% Potassium chloride, 20% Glycerol, 0.05% DTT, 0.49% Glutathione |
| Accession#: | Q9BZ95 |
| Alternative Names: | DKFZp667H044/FLJ20353/Histone lysine N methyltransferase NSD3 |
| Tag: | GST |
| Amino Acid Sequence: | MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGL EFPNLPYYI DGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGA VLDIRYGVSRIAYSKDFETLK VDFLSKLPEMLKMFEDRLCHKTYLNGD HVTHPDFMLYDALDVVLYMDPMCLDAFPKLV CFKKRIEAIPQIDKYLK SSKYIAWPLQGWQATFGGGDHPPKSDLEVLFQGPLGSEGDKS FAEGQT SINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKV IG KVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCP AGDRCQNQCF TKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGE LIDEEECRLRIKRAHENSVTN FYMLTVTKDRIIDAGPKGNYSRFMNHS CNPNCETQKWTVNGDVRVGLFALCDIPAGM ELTFNYNLDCLGNGRTEC HCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRK IKTEPKQMHE D |
| Sequence Similarities: | Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.Contains 1 AWS domain.Contains 4 PHD-type zinc fingers.Contains 1 post-SET domain.Contains 2 PWWP domains.Contains 1 SET domain. |
| Expression System: | E. coli |
| Protein Length: | Protein fragment; 1021 to 1322 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0113 | Human NSD1 Knockout Cell Line 4bp deletion | Inquiry |
| ◆ Research Kits | ||
| EKIT-0287 | NSD1 Chemiluminescent Assay Kit | Inquiry |
| EKIT-0494 | NSD3 Chemiluminescent Assay Kit | Inquiry |
| EKIT-0498 | NSD3 Chemiluminescent Assay Kit | Inquiry |
| EKIT-0502 | NSD2 Chemiluminescent Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| nsd1 | NSD2 | NSD3 | NSMCE2 |
| NSUN1 | NSUN2 | NSUN3 | NSUN4 |
| NSUN5 | NSUN6 | NSUN7 | |
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