| Cat.No.: | PE-1892 |
| Product Name: | RIZ1 (human recombinant) |
| Description: | Retinoblastoma protein-interacting zinc finger protein 1 (RIZ1), also known as PRDM2, is a SAM-dependent histone methyltransferase that specifically methylates histone H3 on lysine 9. RIZ1 contains 8 zinc-finger motifs and 1 PR domain. The RIZ gene encodes two different proteins, RIZ1 and RIZ2. RIZ1 is a tumor suppressor that can arrest the cell cycle and induce apoptosis. RIZ2 however, is a proto-oncoprotein lacking the N-terminal PR domain containing the methyltransferase activity. When RIZ1 is silenced or mutated, the reduced methyltransferase activity can lead to inheritable changes in chromatin methylation and gene expression patterns. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 49.5 kDa |
| Purity: | ≥95% (by SDS-PAGE) |
| Species: | human |
| Accession#: | Q13029 |
| Alternative Names: | KMT8;PRDM2;PR Domain Zinc Finger Protein 2;Retinoblastoma Protein-interacting Zinc Finger Protein |
| Tag: | GST |
| Expression System: | E. coli |
| Protein Length: | 2-200 (C-terminal truncation) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0119 | Human RING1 Knockout Cell Line 1bp deletion | Inquiry |
| CL-0401 | Human RIF1 Knockout Cell Line 37bp insertion | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0178 | Human RIG-I/DDX58 peptide | Inquiry |
| ◆ Antibodies | ||
| EAb-1750 | RING1 Polyclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-1892 | RIZ1 (human recombinant) | Inquiry |
| Related Gene / Proteins | |||
| RIF1 | RIG-I | RING1 | RING1B |
| RIZ1 | |||
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